| 抗胃溃疡药去氢延胡索甲素的半合成 |
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| 引用本文： | 刘润民,赵守训,王明时,闵知大,刘成基.抗胃溃疡药去氢延胡索甲素的半合成[J].中国药科大学学报,1982(1):21-23. |
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| 作者姓名： | 刘润民 赵守训 王明时 闵知大 刘成基 |
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| 作者单位： | 南京药学院 研究生 |
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| 摘 要： | 本文参考半合成13-甲基小檗碱的方法,初次用掌叶防己碱(巴马汀)为原料半合成制备了抗胃溃疡药去氢延胡索甲素(脱氢延胡索碱)。本实验方法为利用国产天然资源掌叶防己碱半合成生产抗胃溃疡病药去氢延胡索甲素提供了一个方便而经济的途径。
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A Semisynthesis of Dehydrocorydaline From Palmatine |
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| Liu Runmin,Zhao Shouxun,Wang Mingshi,Min Zhida and Liu Chengji.A Semisynthesis of Dehydrocorydaline From Palmatine[J].Journal of China Pharmaceutical University,1982(1):21-23. |
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| Authors: | Liu Runmin Zhao Shouxun Wang Mingshi Min Zhida and Liu Chengji |
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| Abstract: | This paper describes a method for semisvnthesis of dehydrocorydaline (1)-a drug used for peptic ulcer. This method is similar to that of semisynthesis of 13-methyl-berberine. First, under concentrated alkaline medium the acetonepalmatine was obtained. Then acetonepalmatine reacted with methyliodide in sealed tube to give dehydrocorydaline iodide (33% yield), and converted to its chloride by ordinary method. So the synthesis of dehydrocorydaline from palmatine is very convenient and economical. |
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