稳定性同位素技术对锌生物利用率的研究

锌是人体必需微量元素之一 ,锌稳态主要通过改变肠道吸收效率和内源性排泌 ,即调节生物利用率来实现。研究锌的生物利用率对全面理解锌的代谢和可靠评价人群锌营养状况起着重要的作用。稳定性同位素是目前研究矿物元素生物利用和代谢的有效工具。锌的稳定性同位素可以作为示踪物安全应用于所有人群而无放射性危害。自 80年代以来 ,许多不同的稳定性同位素方法被发展起来用以分析锌的吸收代谢 ;然而 ,一些方法学的问题尚待解决。此外 ,分析仪器的发展和应用不仅使锌稳定性同位素的应用成为可能 ,也大大降低了该技术的难度和成本。本文主要对其发展历史、应用特点、主要的研究方法及分析技术做一综述。

Studies on the zinc bioavailability using stable isotope techniques

Zinc is one of essential trace elements in humans. Zinc homeostasis is mainly regulated by the changes of intestinal absorption efficiency and endogenous excretion, namely the regulation of bioavailability. Studies on zinc bioavailability play an important role on a thorough understanding of zinc metabolism and reliable assessment on population zinc status. Stable isotopes are valuable tools for research on mineral bioavailability and metabolism. Zinc stable isotopes can be used for all population as tracers with no exposure to radiation. Since 1980s' many different stable isotope methods have been applied to the zinc metabolism research. However, limitations to these approaches and methodological problems remain to be resolved. In addition, the introduction and development of new analytical instruments not only make it possible to use zinc stable isotope, also greatly diminish the difficulty and cost on it. The paper is mainly focused on the zinc bioavailability and present a review of its development history, main research methods and analytical skills.