豨莶草水煎粉剂对小鼠肺毒性研究

目的：观察豨莶草水煎粉剂不同剂量连续灌胃给药与停药2周后，对小鼠肺脏的毒性作用 。方法：昆明种小鼠随机分为4组：正常组，豨莶草水煎粉剂不同剂量(3.01,1.0,0.3 g·kg-1)组，每组40只。分别于7,14,21 d与停药2周后每组处理10只小鼠，取肺组织计算脏器指数及进行病理切片检查。结果：豨莶草水煎粉剂3.0 g·kg-1剂量组14,21 d肺指数有增高趋势，肺组织病理变化明显。停药2周后， 肺毒性变化消失。结论：豨莶草水煎粉剂对小鼠肺脏有一定毒性, 其毒性是可逆的。

An experimental study on pulmonary toxicity water extracts of Siegesbeckia pubescens on mice

Objective: The pulmonary toxicity of water extract of Siegesbeckia pubescens has been studied an mice following subchronic oral administration route. Method: Mice were randomly grouped and administered with the water extract of S. pubescens at dosages of 3.0,1.0,0.3 g·kg-1 and saline respectively. 10 mice of each group were sacrificed on the day of 7 th, 14 th, 21 th, and 2 weeks after stopping administration, histological changes of the lung were examined. Result: The water extract of S. pubescens at dosage of 3.0 g·kg-1 increased the lung index on the of day 14 th and 21 th, significant histopathological damages were observed. The histopathological changes were disappeared after stopping administration for 2 weeks. Conclusion: The water extract of S. pubescens has a pulmonary toxic effect on mice, and the toxic effect is reversible.