2型糖尿病家系胰岛素抵抗与血清抵抗素水平的相关性研究

目的 了解2型糖尿病家系人群胰岛素抵抗与血清抵抗素水平的相关性,初步阐述抵抗素在胰岛素抵抗发病机制中的作用.方法 检测2型糖尿病家系一级亲属89例(实验组)的血清抵抗素、血脂、胰岛素等水平,并与血糖正常的非糖尿病家系者(对照组)进行对比分析,考察其血清抵抗素水平变化与胰岛素抵抗的相关性.结果 2型糖尿病家系一级亲属FINS、2h INS、TG、血清抵抗素、HOMA-IR的水平显著高于对照组(P＜0.01),一级亲属的HDL-C水平显著低于对照组(P＜0.05),两组的FPG、2h PG、TC、LDL-C水平的比较无显著性差异(P＞0.05).血清抵抗素与BMI、FINS、2h INS、TC、HOMA-IR呈正相关(P＜0.01),与2h PG呈负相关(P＜0.05),与FPG、TG、HDL-C、LDL-C无显著相关性(P＞0.05).BMI、FPG、2h PG、血清抵抗素为2型糖尿病家系一级亲属胰岛素抵抗的危险因素.结论 2型糖尿病家系血糖正常的一级亲属存在显著的胰岛素抵抗,其抵抗素对胰岛素抵抗程度有明显的影响.

The correlation of insulin resistance and serum resistin levels of type 2 diabetes families

【Objectives】 To find out the insulin resistance of type 2 diabetes families and their correlation with the serum resistin levels,and to describe the resistance role of resistin in the pathogenesis of insulin.【Methods】 89 first degree relatives of type 2 diabetes families(experimental group) were selected and their serum resistin,lipids and insulin levels were detected,and compared with normal blood glucose in non-diabetic families(control group),the correlation of serum resistin levels and insulin resistance was analyzed.【Results】 Type 2 diabetes families first-degree relatives’ FINS,2h INS,TG,serum resistin,HOMA-IR levels were significantly higher(P <0.01),first-degree relatives’ HDL-C level was significantly lower than the control group(P <0.05),the FPG,2h PG,TC,LDL-C levels showed no significant difference(P >0.05).Serum resistin and BMI,FINS,2h INS,TC,HOMA-IR were positively correlated(P <0.01),serum resistin and 2h PG was negatively correlated(P <0.05),serum resistin and FPG,TG,HDL-C,LDL-C was no significant correlation(P >0.05).BMI,FPG,2h PG,serum resistin levels were the risk factors for insulin resistance of family relatives of type 2 diabetes families.【Conclusions】 The first-degree relatives of type 2 diabetes families have significant insulin resistance,resistin has a significant impact with their insulin resistance.