不同剂量丁丙诺啡对乳腺癌术后镇痛效果的比较

目的比较两种剂量丁丙诺啡对乳腺癌术后的镇痛效果。方法选择全麻择期乳腺癌根治术成年患者120例,ASAⅠ~Ⅱ级,随机分为两组,A组60例术后静脉输注丁丙诺啡0.1μg/(kg.h);B组60例术后静脉输注丁丙诺啡0.3μg/(kg.h)。采用视觉模拟评分法(VAS评分)评价术后6、12、24和48 h的疼痛程度,于各时点行镇静评分及Prince-Henry评分,监测呼吸频率(RR),记录不良反应的发生情况。结果两组年龄、体重、ASA分级、并发症比较差异均无统计学意义(P>0.05)。与A组比较,B组镇痛效果满意,VAS评分、镇静评分、Prince-Henry评分、RR及恶心发生率均有统计学差异(P<0.05)。结论静脉输注丁丙诺啡0.3μg/(kg.h)可有效缓解乳腺癌手术后患者疼痛,且不良反应少。

Effects of Different Doses of Buprenorphine on Postoperative Analgesia in Breast Cancer Patients

Objective To study the effect of buprenorphine on postoperative analgesia in breast cancer patients.Methods A total of 120 patients with breast cancer of ASA I or II undergoing selective operation under general anesthesia were randomly divided into two groups(n=60/group).Group A was administered with continuously intravenous buprenorphine at 0.1 μg/kg·h-1 after operation,and Group B with continuously intravenous buprenorphine at 0.3 μg/kg·h-1 after operation.The intensity of pain was assessed using VAS scoring at 6,12,24 and 48 hours after operation,as well as side effects and respiratory rate(RR).Results There were no significancely differences in age,body weight,ASA class and complication between the two groups(P>0.05).Group B achieved a better postoperative analgesic effect than group A.There existed significancely differences in VAS scoring,side effects and RR after operation(P<0.05).Conclusion Continuously intravenou infusion of buprenorphine at 0.3 μg/kg·h-1 can provide an effective postoperative analgesia without respiratory depression and with few side effects.