舒费美对慢性阻塞性肺病患者肺功能影响的临床研究

目的：探讨慢性阻塞性肺疾病（ＣＯＰＤ）患者每日１次和２次口服茶碱的血清浓度变化及对２４ｈ肺功能的影响。方法：２０例严重ＣＯＰＤ患者，在治疗前，先检测２４ｈ肺功能进行量化评估，然后用双盲交叉设计的方法，随机先后进行茶碱每日２次和１次用法的研究，测定血清茶碱浓度并重复治疗前的研究内容。结果：茶碱２０：００服用在次日４：００达峰值，８：００服后在１２：００达峰值，谷值均在２０：００，在４：００的茶碱浓度每１次高于２次者，在１６：００则相反（Ｐ〈０．０５），茶碱两种方法的治疗对肺功能有相似但明显的改善（Ｐ＝０．００１）。每日１次用法改善症状明显（Ｐ＝０．００２３）。结论：口服茶碱缓解片在清晨有较高的血清浓度较低的血茶碱水平（５～１０ｍｇ／Ｌ），对肺功能就有改善作用，且副作用小。

Effects of thiophylline SHuFuMEI on Lung function in patients with chronic obstructive pulmonary disease clinical study

Purpost: To evaluate the effects of theophylline given by twice-daily and oncedaily on 24 hour lung function in severe COPD. Method: Fwenty patients wee assessed. Before, theop hyline given on lung function and polysomnography wer performed, and baseline scores of symptoms were in vestigated. And then, with double blind crossover in design, twicedaily theophylline closing (TD) or once-daily theophylline closing (OD) was given in a randowly assigned seguence, and serum theophylline concentation (STC) was measured, and other puysiological testings were similar to baseline measurements. Result: The peak STC occaved at 4am after administration at 8pm, and that occurred of 12am after administration of 8am, and the trough STC occurred at 8pm in both treatment. STC of OD was higher than that of Tdat 4AM, but TD was higher than OD AT 4PM (P<0.05). There was a similar but signifcant improvement of the lung function after theophylline given for TD or OD (P<0.001).symptoms inproved in both groups, but OD was better (P=0.0023). Conclusion: There was higher STC in early morning in both treatment. The improvement of lung function may well be obtained of lower STC, and the side effects attributed to SHVFUMEI are rare.