| 骨碎补总黄酮、淫羊藿总黄酮联合防治小鼠骨质疏松的疗效观察 |
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| 引用本文： | 肖润梅,陈勇. 骨碎补总黄酮、淫羊藿总黄酮联合防治小鼠骨质疏松的疗效观察[J]. 中国基层医药, 2008, 15(8) |
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| 作者姓名： | 肖润梅 陈勇 |
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| 作者单位： | 1. 湖北省新华医院药剂科,湖北省武汉,430015
2. 湖北大学中药生物技术省霞点实验室 |
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| 基金项目： | 湖北大学校科研和教改项目 |
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| 摘 要： | 目的 研究骨碎补总黄酮、淫羊藿总黄酮对实验性骨质疏松症小鼠骨代谢生化指标的影响.方法 采用维甲酸灌胃造成小鼠实验性骨质疏松症模型,同时灌服高、中、低三种剂量的含有骨碎补总黄酮、淫羊藿总黄酮的供试药,检测小鼠血清总碱性磷酸酶(AKP)、羟脯胺酸/肌酐值(HOP/Cr)、钙离子(Ca2+)、骨钙素(BGP)的变化.结果 三个给供试药剂量组的血清总碱性磷酸酶含量与模型组相比均升高,血清骨钙素、羟脯胺酸/肌酐、血清钙离子与模型组相比均下降(P＜0.01或P＜0.05).结论 骨碎补总黄酮、淫羊藿总黄酮对维甲酸所致小鼠骨质疏松症有一定的防治作用.
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| 关 键 词： | 淫羊藿 骨碎补 黄酮类 骨质疏松 维甲酸 |
Effect of the combination of two kinds of total flavones on osteoporsis mice |
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| XIAO Run-mei,CHEN Yong. Effect of the combination of two kinds of total flavones on osteoporsis mice[J]. Chinese Journal of Primary Medicine and Pharmacy, 2008, 15(8) |
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| Authors: | XIAO Run-mei CHEN Yong |
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| Abstract: | Objective To study the effects of epimedium koreanum flavones and davallia mariesil flavones on osteoporosis mice induced by retinoie acid.Methods The osteoporosis mice were induced by retinoic acid and then were fed with epimedium koreanum flavones and davallia mariesil flavones.The biochemical markers in serum were observed.Results The data showed that the blood AKP were higher in mice treated with two total flavones than mice in model group,the blood HOP/Cr,BGP,Ca2+ were lower in treated mice than model group(P＜0.01 or P＜0.05).Conclusion This study suggests that those two total flavones can effectively treat the osteoporosis mice induced by retinoic acid. |
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| Keywords: | Epimedium koreanum Davallia mariesii Falvones Osteoporosis Retinoic acid |
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