The effect of immunoglobulin M-enriched intravenous immunoglobulins against bacterial infections and on the neutralization of bacterial toxins

Studies on the Efficacy of Immunoglobulin M Enriched Intravenous Immunoglobulins against Bacterial Infections and in Neutralization of Bacterial Toxins. An essential component of the new i.v. immunoglobulin product Pentaglobin is immunoglobulin M (IgM), which is concentrated in this preparation. The efficacy of this IgM containing preparation in comparison to conventional i.v. immunoglobulins was demonstrated in mouse protection tests and by in vitro neutralization of bacterial toxins. The IgM containing immunoglobulin preparation has significantly higher protection rates against gram-positive and gram-negative bacteria in mouse protection tests compared to immunoglobulin G (IgG) preparations. Bacterial toxins of Pseudomonas aeruginosa and Staphylococcus aureus are likewise more effectively neutralized by the IgM containing immunoglobulin preparation.