The effect of prolonged cold and starvation and subsequent refeeding on plasma lipids and glucose of normal men |
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| Authors: | M Mager P F Iampietro |
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| Affiliation: | 1. Department of Urology, Medical University of Vienna, Vienna General Hospital, Vienna, Austria;2. Department of Urology, University of Udine, Udine, Italy;3. Department of Urology, Ludwig-Maximilians-University Munich, Munich, Germany;4. Center for Advanced Laparoscopic and Robotic Surgery, Glickman Urologic and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA;5. Department of Urological Oncology, Fox Chase Cancer Center, Temple University School of Medicine, Philadelphia, PA, USA;6. Centre for Mechanics of Biological Materials, University of Padua, Padua, Italy;7. OLV Robotic Surgery Institute, Aalst, Belgium;8. Department of Urology, San Luigi Gonzaga Hospital-Orbassano, University of Turin, Turin, Italy;9. Swedish Urology Group, Seattle, WA, USA;10. Vattikuti Urology Institute, Henry Ford Hospital, Detroit, MI, USA;11. Urology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA;12. Department of Urology, Mayo Medical School and Mayo Clinic, Rochester, MN, USA;13. Department of Urology, University of Texas MD Anderson Cancer Center, Houston, TX, USA;14. University of Southern California Institute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA;1. Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, the Republic of Korea;2. Division of Mechanical and Biomedical Engineering, Ewha Womans University, Seoul 03760, the Republic of Korea;3. Intelligent Wave Engineering Team, Korea Research Institute of Standards and Science, Daejeon 34113, the Republic of Korea;4. Department of Precision Measurement, University of Science and Technology (UST), Daejeon 34113, the Republic of Korea;5. Department of Materials Science and Engineering, Korea University, Seoul 02841, the Republic of Korea;6. Department of Mechanical Engineering, University of California, Berkeley, CA 94720, USA;7. School of Advanced Materials Science and Engineering, Sungkyunkwan University (SKKU), Suwon 16419, the Republic of Korea;1. Louisiana State University, NBER and IZA, United States;2. T. Rowe Price, United States;1. Laboratório de Farmacognosia, Departamento de Ciências Farmacêuticas, Universidade Federal de Pernambuco, Recife, PE, Brazil;2. Faculdade Pernambucana de Saúde, Recife, PE, Brazil;3. Setor de Microscopia Eletrônica, Laboratório de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Recife, PE, Brazil;1. Department of Clinical Pharmacy, College of Pharmacy, Taif University, Taif, Saudi Arabia;2. Pharmacology Department, Faculty of medicine, Tanta University, Tanta, Egypt;3. Pharm D, College of Pharmacy, Taif University, Taif, Saudi Arabia |
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| Abstract: | Six healthy young men served as test subjects in a 6-week study which consisted of a 2-week control period, a 2-week starvation-plus-cold period, and a 2-week period of refeeding with restricted diets. Plasma glucose levels declined to 20 per cent below control values within 2 days of cold and starvation, and remained there thereafter. Restoration to control levels was achieved during the first day of refeeding. Plasma cholesterol, phospholipids and total lipids increased during the early phases of cold and starvation, and were restored to control values by the end of the fourteenth day. Plasma free fatty acids (FFA) rose to over 200 per cent of control levels within 2 days, and remained constant thereafter. With refeeding, plasma cholesterol, phospholipids and total lipids “overshot” to levels of 20–40 per cent of control values; whereas, FFA declined to nadir levels which averaged 32 per cent below control concentrations. The reciprocal changes in FFA and other lipids suggest that in man, as in experimental animals, exuberant lipogenesis may occur when refeeding is instituted following depletion of endogenous substrates. |
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