代谢综合征及其诊断组分对心脏功能的影响

目的:探讨代谢综合征(MS)及其诊断组分对心脏功能的影响.方法:在浙江省东部沿海一个相对隔离地区邀请当地居民参加研究,测量身高、体重、腰围、臀围及血压.运用标准化问卷收集饮酒、吸烟、高血压用药等资料.抽空腹血利用全自动生化检测仪分析检测血糖和血脂.采用MY LAB 30超声心动图检查仪,进行超声心动图检查,测量并计算LVEF、E/A比值、DTE、Tei指数等.MS根据MS组分的数日将人群分为四组:正常组、1个危险因素组、2个危险因素组和MS组.采用方差和协方差分析进行统计.结果:843例受检者,包括288(34.2%)名女性,191(22.7%)例高血压患者,其中82(42.9%)例接受抗高血压药物治疗.与正常组相比,MS患者随着诊断组分的增加,LVEF和E/A比值逐渐下降,DTE和Tei指数逐渐增加(P<0.001).结论:在自然人群中,随MS诊断组分的增加,心脏逐渐出现收缩和舒张功能受损的改变.

Impact of the metabolic syndrome on cardiac function in a Chinese population

Objective:To investigate the association of the diagnostic components of metabolic syndrome(MS) with the cardiac function in Chinese. Methods:In 843 subjects recruited in Zhejiang province,we measured each participant's body height,body weight,waist and hip circumferences,and blood pressure. The observers were administered a standardized questionnaire to collect information on smoking habits,alcohol consumption and use of antihypertensive drugs. Echocardiography was performed on each subject according to the recommendations of the American Society of Echocardiography for the measurements of LVEF,E/A ratio,DTE,and Tei index. Venous blood was sampled for biochemical measurements. Results:843 subjects included 288(34.2%) women,and 191(22.7%) hypertensive patients,of whom 82(42.9%) took antihypertensive drugs. Compared to subjects in normal group,MS patients had significiantly lower LVEF(P = 0.049) and E/A ratio(P < 0.001),and higher DTE(P < 0.001) and Tei index(P < 0.001). Moreover,LVEF and E/A ratio decreased,and DTE and Tei index increased, with the number of MS components. Conclusion:The number of MS-diagnosis components was associated with the impairment of cardiac function.