多肿瘤标志物蛋白芯片检测技术对肺癌的诊断价值分析

目的研究多肿瘤标志物蛋白芯片检测技术对肺部恶性肿瘤的诊断价值。方法同期住院患者分为三组：肺癌组（78例）、肺部良性病变组（118例）、对照组（68例），用多肿瘤标志物蛋白芯片检测系统测定血清中12种肿瘤标志物的水平。结果癌胚抗原（CEA）、糖原125（CAl25）、铁蛋白（Fer）和糖原242（CA242）的血清水平肺癌组明显高于肺部良性病变组和对照组。CEA、CAl25、Fer和CA242检测诊断肺癌的灵敏度分别为41．O％、35．9％、26．9％、17．9％，特异度分别为89．8％、86．0％、86．6％、95．7％。12种肿瘤标志物中单项检测阳性诊断肺癌的敏感度和特异度分别为57．7％和72．0％，二项阳性为32．1％和88．7％，三项阳性为24．4％和96．8％，四项阳性为15．4％和98．9％。结论多肿瘤标志物蛋白芯片检测方法对肺癌诊断的阳性率较高，当三项以上同时阳性时虽然敏感度下降，但特异度可高达96．8％，对于初步判断病灶的恶性性质有一定的帮助。

Diagnostic value of multiple tumor marker protein biochip detective system for patients with lung cancer

Objective To evaluate diagnostic values of multi-tumor markers protein biochip detective system for lung cancer. Methods Patients with lung cancer group （78 cases） ,benign pulmonary diseases group （ 118 cases） and control group （68 cases） were enrolled. Twelve tumor markers in serum （ AFP, CEA, NSE, CA125, CA153, CA242, CA199, PSA, f-PSA, FERβ,-HCG and HGH） were measured by the multi-tumor markers protein biochip detective system. Result The serum levels of CEA, CA125, Fer and CA242 in the lung cancer group were much higher than those of the other two groups. There were no significant differences of serum levels and posi- tive rates of other tumor markers among three groups. The sensitivity of CEA, CA125, Fer and CA242 were 41.0%, 35.9%, 26. 9% and 17. 9% respectively, the specificity of 89. 8%, 86. 0%, 86. 6% and 95.7% respectively. Conclusions The multi-tumor markers protein biochip detective system has diagnostic values in lung cancer. When more than three markers axe positive simultaneously, the sen- sitivity was 24. 4% ,and the specificity was 96.8%. The result could help detect the character of tumor.