高血压大鼠局部脑缺血再灌流边缘区超微结构改变

用透射电镜观察了肾血管性高血压大鼠局部脑缺血早期再灌流及持续缺血９个实验组和假手术组缺血边缘区超微结构改变。结果发现：局部脑缺血０．５至３小时再灌流均较相应持续缺血神经元损害轻；缺血６小时再灌流，神经元细胞器固缩，并有暗黑颗粒沉积。表明在高血压鼠局部脑缺血早期，恢复血流有利于边缘区神经元恢复。

The sequential observation on ultrastructure changes of perifocal areas of ischemia following middle cerebral artery occlusion and reperfusion in hypertensive rats.

sing the electron microscope, we sequetially observed the ultrastructure changes of the perifocal areas of ischemia following permanent or temporary occlusion of the middle cerebral artery (MCA) in the renovascular hypertensive rats (RHR). It was found that: (1)in the rats with permanent MCA occlusion for 1.5 bours to 6 hours the neuronal injury was more severe than in the ones with 1 hour to 3 hours reperfusion following MCA occlusion for 0.5 to 3 hours; (2) in the rats with 6 hours reperfusion following MCA occlusion for 6 hours, the majority of neurons were found to be shrunk, and there were some dark granules in mitochondria. The results show that at the earlier stage of focal cerebral ischemia, it is advantageous for the perifocal areas of ischemia to be renewed blood flow in RHR.