Hyperbaric oxygen, hypothermia, and cerebral ischemia in the dog |
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| Authors: | R H Patterson C K McSherry M S Schwartz |
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| Affiliation: | 1. Companion Animal Clinic, School of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece;2. Department of Radiology, AHEPA University General Hospital of Thessaloniki, Thessaloniki, Greece;1. Intensive Care, CHU-Charleroi, Université Libre de Bruxelles, 6042 Charleroi, Belgium;2. Anesthesiology, CHU-Charleroi, Université Libre de Bruxelles, 6042 Charleroi, Belgium;3. Pharmacognosy, Bioanalysis and Drug Development & Analytical Platform (APFP), Faculty of Pharmacy, Université Libre de Bruxelles, 1050 Brussels, Belgium;4. Laboratory of Experimental Medicine (ULB 222 Unit), Medicine Faculty, Université Libre de Bruxelles, CHU de Charleroi, 6110 Montigny-le-Tilleul, Belgium;1. Small Animal Surgery Clinic, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland;2. Companion Animal Clinic, School of Veterinary Medicine, Aristotle University of Thessaloniki, 11 S. Voutyra Street, 54627 Thessaloniki, Greece;3. Department of Surgery, Faculty of Veterinary Medicine, University of Thessaly, 224 Trikalon Street, 43100 Karditsa, Greece;4. Laboratory of Pathology, School of Veterinary Medicine, Aristotle University of Thessaloniki, University Campus, 54124 Thessaloniki, Greece;1. Laboratório de Metabolismo e Endocrinologia Comparada, Departamento de Fisiologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Sarmento Leite 500, Porto Alegre – RS, Brazil. CEP: 90050-170;2. Departamento de Medicina Animal, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Bento Gonçalves 9090, Porto Alegre – RS, Brazil. CEP: 91540-000;3. Hospital de Clínicas Veterinárias, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Bento Gonçalves 9090, Porto Alegre – RS, Brazil. CEP: 91540-000;4. Setor de Patologia Veterinária, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Bento Gonçalves 9090, Porto Alegre – RS, Brazil. CEP: 91540-000;5. Departamento de Patologia Clínica Veterinária, Universidade Federal do Rio Grande do Sul (UFRGS), Av. Bento Gonçalves 9090, Porto Alegre – RS, Brazil. CEP: 91540-000 |
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| Abstract: | A new method to arrest the cerebral circulation of a dog is described, in which the major intraspinal arteries surrounding the cervical spinal cord are divided or thrombosed in a preliminary operation. After the animal has recovered from the procedure, pneumatic cuffs are inflated about the neck which block the extraspinal arteries and interrupt all flow of blood to the head.The effects of cerebral ischemia were studied in dogs breathing air or oxygen at 3 ATA at body temperatures of 37°C. and 28°C. and the data subjected to probit analysis. Seven minutes of ischemia were followed by a 50% mortality in normothermic dogs breathing air. A period of 94 minutes was required to attain the same mortality in hypothermic dogs, regardless of whether air or hyperbaric oxygen was respired.The duration of ischemia required to induce a moderate neurological deficit was 6 minutes in normothermic animals breathing air and 8 minutes in those administered oxygen. Hypothermic animals sustained a moderate neurological deficit after 29 minutes of cerebral ischemia if supplied air and after 34 minutes if supplied hyperbaric oxygen. |
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