奥曲肽治疗大鼠应激性胃粘膜损害的实验研究

为探讨奥曲肽防治应激性溃疡的机制,对大鼠严重脑损伤后应激性胃粘膜损害,给予不同剂量的奥曲肽(4μg·kg~(-1)·12h~(-1)和6μg·kg~(-1)·12h~(-1))治疗,测定胃粘膜血流(GMBF)等多项指标,并与生理盐水对照组、正常对照组及法莫替丁治疗组进行比较。结果表明,奥曲肽治疗组能显著减轻胃粘膜损害指数(P<0.01),增加GMBF(P<0.01),升高跨胃粘膜电位(P<0.01),增加胃粘膜氨基己糖及磷脂含量(P<0.01)。奥曲肽具有良好的胃粘膜细胞保护作用,对治疗大鼠重度脑损伤后所致胃粘膜损害具有良好疗效。

EXPERIMENTAL STUDY OF THE TREATMENT OF TRAUMATIZED IRRITABLE GASTRIC MUCOSA IN RATS WITH OCTREOTIDE

To explore the actual mechanism of the curative and preventive effects of oc-treotide in the treatment of the irritable gastric ulcer, the authors administered different dosages of Octreotide to rats, of which their brain have been severely injured to induce traumatic irritable gastric mucosae. The gastric mucosal blood flow (GMBF) and other indexes were measured. Compared treated group with control groups of blank, normal saline and treated with famotidine. The results showed that Octreotide markedly decreased injury index of the gastric mucosa, increased GMBF, the electrical potential difference, levels of hexosamine, and phospholipids in gastric mucosa. Octreatide has favourable protective effect to gastric mucosa and promising curative effect in the treatment of tuaumatic irritable gastric mucosa induced by severe brain injury in the rat.