复方樟柳碱治疗AION的微视野研究

目的:探讨复方樟柳碱(compound anisodine hydrobromide injection)治疗前部缺血性神经病变(anterior ischemic optic neuropathy,AION)的微视野的临床疗效。方法:AION患者66例107眼,采用患侧颞浅动脉旁皮下注射2mL,1次/d,10d一个疗程,基础疗程为四个,依照病情可增加1~2个疗程,观察眼底视盘形态与视功能改变,以反映其疗效的临床价值。结果:采用患侧颞浅动脉旁皮下注射四个疗程后,视力恢复有显著疗效者约55%,治疗第三、四疗程与第一、二疗程比较,视野缺损度改善有显著性差异(P<0.05),且患侧颞浅动脉旁皮下注射第四疗程视功能恢复最佳。结论:复方樟柳碱可以有效改善AION患者的视力和视野缺损度,是一种治疗AION方便、快捷、安全的方法。

Microperimetry study of compound anisodine hydrobromide injection for the treatment of anterior ischemic optic neuropathy

AIM:To study the clinical effect of compound anisodine hydrobromide injection for the treatment of anterior ischemic optic neuropathy (AION) on microperimetry.METHODS:Totally 66 cases (107 eyes) with AION were treated by subcutaneous injection of the affected side next to the superficial temporal artery 2mL, 1 time/day, a course of 10 days. The basic courses were 4, according to the condition it can increase 2-3 courses. Fundus optic disc morphology and changes of visual function were observed in order to reflect the clinical value.RESULTS:Vision recovery had significant effect in 55% cases after subcutaneous injection of the affected side next to the superficial temporal artery for 4 courses. The 1st and 2nd courses compared with the 3rd and 4th courses, visual field defect degrees improved significantly(P<0.05) and the visual function in the 4th course of subcutaneous injection of the affected side next to the superficial temporal artery recovered best.CONCLUSION:Compound anisodine hydrobromide injection can effectively improve the visual acuity and visual field defect degrees in AION patients, which is convenient, fast and safe.