Anticoagulant effects of sulphonated polyurethanes. |
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| Authors: | J H Silver A P Hart E C Williams S L Cooper S Charef D Labarre M Jozefowicz |
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| Affiliation: | Department of Chemical Engineering, University of Wisconsin-Madison 53706. |
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| Abstract: | Sulphonated polyurethanes have been shown to have excellent blood contacting properties. In this paper, similar polyurethanes which are water soluble have been investigated to determine their influence on thrombus formation. These polymers were shown to delay clotting times in the following ways: by direct complex formation between the polymer and thrombin; by interference with fibrin polymerization; and by complex interactions between polymer, thrombin, plasma antiproteases and fibrinogen in plasma. |
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