糖尿病性视网膜病变与血脂、脂蛋白水平的相关分析

目的：探讨血脂、脂蛋白、载脂蛋白与糖尿病性视网膜病变（ＤＲ）发生发展的关系。方法：对３０８例Ⅱ型糖尿病患者的血脂、脂蛋白、载脂蛋白资料进行分析总结。结果：血清总胆固醇（ＴＣ）、高密度脂蛋白（ＨＤＬ）、载脂蛋白Ａ（ＡＰＯ－Ａ），ＡＰＯ－Ｂ在有ＤＲ组较无ＤＲ组明显增高（Ｐ〈０．０５）。增殖期ＤＲ组中，ＴＣ，三酰甘油（ＴＧ），载脂蛋白ＡＰＯ－Ｂ较单纯期ＤＲ组非常显著或显著增高（Ｐ〈０．０１，Ｐ〈０．０５

Correlation of diabetic retinopathy with serum lipid and lipoprotein levels

Objective: To observe and investigate the correlation between serum lipids, lipoproteins and apolipoproteins and the development of diabetic retinopathy (DR). Methods: Serum levels of lipids, lipoproteins and apolipoproteins of 308 diabetic patients were measured and analyzed. Results: The total cholesterol (TC), high density lipoprotein(HDL), apolipoprotein A(APO A) and apolipoprotein B(APO B) in DR group were significantly higher than those without DR ( P <0.05). TC, triglyceride (TG) and APO B in the group with proliferative DR (PDR) were significantly or very significantly higher than those with background DR (BDR) ( P <0.05 or P <0.01). Stepwise Logistic regression analysis revealed that the level of TC was correlated with DR. Conclusion: Abnormal metabolism of serum lipid and lipoprotein, especially the level of TCs, influence the development and progression of DR. Thus strict control of the level of serum lipids and strict controll of the level of blood sugar are equally important in diabetic patients. [