RAD58 (XRS4)—A new gene in the RAD52 epistasis group |
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Authors: | Olga V. Chepurnaya Serguey A. Kozhin Vjacheslav T. Peshekhonov Vladimir G. Korolev |
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Affiliation: | (1) Laboratory of Genetics of Eukaryotes, Department of Molecular and Radiation Biophysics, Petersburg Nuclear Physics Institute, Academy of Sciences of Russia, 188350 Gatchina, Russia |
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Abstract: | The RAD58 (XRS4) gene of Saccharomyces cerevisiae has been previously identified as a DNA repair gene. In this communication, we show that RAD58 also encodes an essential meiotic function. The spore inviability of rad58 strains is not rescued by a spo13 mutation. The rad50 mutation suppresses spore inviability of a spo13 rad58 strain suggesting that RAD58 acts after RAD50 in meiotic recombination. The rad58-4 mutation does not prevent mitotic recombination events. Haploid rad58 cells fail to carry out G2-repair of gamma-induced lesions, whereas rad58/rad58 diploids are able to perform some diploid-specific repair of these lesions. |
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Keywords: | Yeast RAD58 Repair Recombination |
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