| 草豆蔻中一个新的二氢黄酮及其对PC12细胞的神经保护作用 |
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| 引用本文： | 辛本茹,任守娟,李捷.草豆蔻中一个新的二氢黄酮及其对PC12细胞的神经保护作用[J].中国中药杂志,2014,39(14):2674-2678. |
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| 作者姓名： | 辛本茹 任守娟 李捷 |
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| 作者单位： | 山东日照市人民医院 药学部, 山东 日照 276826;山东日照市东港区日照街道卫生院, 山东 日照 276800;山东省医学科学院 药物研究所 天然药物化学研究室, 山东 济南 250062 |
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| 摘 要： | 该文对草豆蔻Alpinia katsumadai中的黄酮类化学成分进行了研究。通过硅胶，Sephadex LH-20等柱色谱和制备液相等多种色谱方法，从草豆蔻95%乙醇提取物中分离得到7个黄酮类化合物。根据理化性质和波谱数据分别鉴定为（2R， 3S）-pinobanksin-3-cinnamate（1）、乔松素（2）、短叶松素（3）、3-O-乙酰基短叶松素（4）、高良姜素（5）、华良姜素（6）、山柰酚-3-甲醚（7）。其中化合物1为新化合物，其他6个为已知化合物。药理活性研究表明，化合物1对皮质酮损伤的PC12细胞有很强的保护作用，其机制可能是通过清除细胞内活性氧发挥效果。
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| 关 键 词： | 草豆蔻 二氢黄酮 PC12 细胞 活性氧 |
| 收稿时间： | 2014/1/25 0:00:00 |
A new flavonone from seeds of Alpinia katsumadai and its neuroprotective effect on PC12 cells |
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| XIN Ben-ru,REN Shou-juan and LI Jie.A new flavonone from seeds of Alpinia katsumadai and its neuroprotective effect on PC12 cells[J].China Journal of Chinese Materia Medica,2014,39(14):2674-2678. |
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| Authors: | XIN Ben-ru REN Shou-juan and LI Jie |
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| Institution: | Department of Pharmacy, People's Hospital of Rizhao, Rizhao 276826, China;Donggang District Community Health Institute, Rizhao 276800, China;Department of Chemistry of Natural Product, Institute of Materia Medica, Shandong Academy of Medical Sciences Ji'nan 250062, China |
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| Abstract: | A new flavonone, named as(2R, 3S)-pinobanksin-3-cinnamate(1), together with six known compounds, pinocembrin(2), pinobanksin(3), 3-O-acetylpinobanksin(4), galangin(5), kumatakenin(6), and 3-methylkaempferol(7), were isolated from a 95% ethanol extract of seeds of Alpinia katsumadai through a combination of various chromatographic techniques, including silica gel and Sephadex LH-20.The structure of compound 1 was elucidated by spectroscopic data analysis.Compound 1 exhibits a potent neuroprotective effect against the corticosterone damaged PC12 cells, which may be underlying the effect by scavenging intracellular ROS. |
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| Keywords: | Alpinia katsumadai flavonone PC12 cell ROS |
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