Epidemiology and risk factors for human papillomavirus infection in a diverse sample of low-income young women |
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| Authors: | Tasneem Shikary David I. Bernstein Yan Jin Gregory D. Zimet Susan L. Rosenthal Jessica A. Kahn |
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| Affiliation: | 1. University of Cincinnati College of Medicine, Cincinnati, OH, United States;2. Division of Infectious Diseases, Cincinnati Children''s Hospital Medical Center, Cincinnati, OH, United States;3. Division of Adolescent Medicine, Indiana University, Indianapolis, IN, United States;4. Division of Adolescent and Behavioral Health, University of Texas, Medical Branch at Galveston, Galveston, TX, United States;5. Division of Adolescent Medicine, Cincinnati Children''s Hospital Medical Center, Cincinnati, OH, United States;1. Immunization Services Division, National Center for Immunization and Respiratory Diseases, CDC, Atlanta, Georgia;2. Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, CDC, Atlanta, Georgia;3. Division of Sexually Transmitted Disease Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, CDC, Atlanta, Georgia;4. Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland;1. Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, United States;2. Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States;3. Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States;4. Department of Otolaryngology, Louisiana State University Health Sciences Center, New Orleans, LA, United States;5. Department of Medicine, Duke University School of Medicine and Duke Cancer Institute, Duke University Medical Center, Durham, NC, United States;1. Department of Orthopedic Surgery, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-Ku, Chiba 2608670, Japan;2. Department of Orthopedic Surgery, University of Tsukuba, Tsukuba, Japan;3. Department of Orthopedic Surgery, Chiba Aoba Municipal Hospital, Chiba, Japan;1. Department of Orthopaedic Surgery, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan;2. Department of Orthopedic Surgery, Chiba University Graduate School of Medicine, Chiba, Japan;3. Department of Orthopedic Surgery, Narita Red-cross Hospital, Chiba, Japan;4. Department of Orthopedic Surgery, Oyumino Central Hospital, Chiba, Japan;1. Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, TN, USA;2. Center for Human Genetics Research, Department of Molecular Physiology & Biophysics, Vanderbilt University School of Medicine, Nashville, TN, USA;1. Institute for Evaluative Research in Medicine, University of Bern, Stauffacherstrasse 78, CH-3014, Bern, Switzerland;2. Department of Orthopaedics, Drammen Hospital, Vestre Viken HF, 3004 Drammen, Norway;3. Quantify Research, Hantverkargatan 8, SE-11221 Stockholm, Sweden;4. LIME/MMC, Karolinska Institutet, Tomtebodavägen 18A, Solna Campus, SE-17177 Stockholm, Sweden;5. Swiss Paraplegics Centre, Guido A. Zäch-Strasse 1, CH-6207 Nottwil, Switzerland;6. Osteoporosis Policlinic, University Hospital of Bern, University of Bern, Freiburgstrasse 18, CH-3008 Bern, Switzerland;7. Department for Orthopedic Surgery and Traumatology, Cantonal Hospital St. Gallen, Rorschacher Strasse 95, CH-9007 St. Gallen Switzerland |
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| Abstract: | BackgroundTwo HPV vaccines prevent infection with HPV-16 and HPV-18, high-risk (cancer-associated) HPV types which together cause approximately 70% of cervical cancers; one vaccine also prevents HPV-6 and HPV-11, which together cause approximately 90% of anogenital warts. Defining type-specific HPV epidemiology in sexually experienced women will help estimate the potential clinical benefits of vaccinating this population.ObjectivesTo examine HPV epidemiology in a diverse sample of sexually experienced women, and to determine factors associated with high-risk HPV and vaccine-type HPV (HPV-6, HPV-11, HPV-16 and HPV-18).Study designCross-sectional study of 13–26-year-old women (N = 409) who completed a questionnaire and provided a cervicovaginal swab. Swabs were genotyped for HPV using PCR amplification. Logistic regression models were used to determine whether participant characteristics, knowledge, and behaviors were associated with high-risk and vaccine-type HPV.ResultsMost women (68.4%) were positive for ≥1 HPV type, 59.5% were positive for ≥1 high-risk type, 33.1% were positive for ≥1 vaccine-type HPV, and 3.5% were positive for both HPV-16 and HPV-18: none was positive for all four vaccine types. In adjusted logistic regression models, Black race (OR 2.03, 95% CI 1.21–3.41) and lifetime number of male sexual partners (OR 4.79, 95% CI 2.04–11.23 for ≥10 partner vs. ≤1 partner) were independently associated with high-risk HPV infection.ConclusionsHPV prevalence was very high in this sample of sexually active young women, but <5% were positive for both HPV-16 and HPV-18, suggesting that vaccination could be beneficial for many individual women who are sexually experienced. |
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| Keywords: | Human papillomavirus Vaccination Cervical cancer Sexually transmitted infection Epidemiology |
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