抑郁症患者急性时相反应蛋白水平检测及其临床意义

目的探讨血清高敏C反应蛋白(hs-CRP)、白蛋白(Alb)、前白蛋白(PA)、转铁蛋白(TF)含量在抑郁症患者诊疗中的临床意义。方法采用溴甲酚绿法测定60例抑郁症患者和40名健康人血清Alb水平,采用免疫比浊法测定其血清hs-CRP、PA、TF水平。结果抑郁症患者血清hs-CRP水平为(5.12±2.07)mg/L,明显高于对照组(1.88±1.29)mg/L,P<0.01];Alb、PA、TF水平分别为(42.6±4.2)g/L、(244±48)mg/L、(1.98±0.42)g/L,均明显低于对照组(46.1±4.6)g/L、(293±52)mg/L、(2.46±0.39)g/L,P<0.01]。Pearson相关分析显示汉密顿抑郁量表(HAMD)总分与hs-CRP呈明显正相关(r=0.592,P<0.01),与Alb、PA、TF呈负相关(r分别为-0.463、-0.525、-0.491,P均<0.01)。结论抑郁症患者体内急性时相反应蛋白(APP)水平存在异常,hs-CRP、Alb、PA、TF水平测定在抑郁症临床治疗中有着重要意义。

The determination and its clinical significance of serum acute phase protein in patients with depression

Objective To investigate the clinical significance of serum high sensitive C reactive protein（hs-CRP）,albumin（Alb）,prealbumin（PA） and transferrin（TF） levels for the diagnosis of patients with depression.Methods The 60 patients with depression and 40 healthy subjects were enrolled,and their serum levels of Alb were determined by bromcresol green.The levels of hs-CRP,PA and TF were determined by immunoturbidimetry.Results The serum hs-CRP level in depression group （5.12±2.07） mg/L] was significantly higher than that in the control group （1.88±1.29） mg/L,P0.01].The levels of serum Alb （42.6±4.2） g/L],PA （244±48） mg/L] and TF （1.98±0.42） g/L] in the depression group were significantly lower than those in the control group （46.1±4.6） g/L,（293±52） mg/L and（2.46±0.39） g/L,P0.01].The Pearson analysis Hamilton depression scale（HAMD） showed a significant positive correlation with hs-CRP（r=0.592,P0.01）,but there was a significantly negative correlation with serum Alb,PA and TF（r=-0.463,-0.525 and-0.491,P0.01）.Conclusions The acute phase protein level（APP） of depression patients is abnormal.It has an important clinical significance in the diagnosis and treatment of depression by determining the levels of serum hs-CRP,Alb,PA and TF.