| 胃癌及癌旁组织中p53基因和Rb基因的研究 |
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| 引用本文： | 王俊茹 王冰. 胃癌及癌旁组织中p53基因和Rb基因的研究[J]. 第三军医大学学报, 1993, 15(3): 198-202 |
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| 作者姓名： | 王俊茹 王冰 |
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| 作者单位： | 第三军医大学西南医院消化科，第三军医大学西南医院消化科，北京市肿瘤研究所，北京市肿瘤研究所，北京市肿瘤研究所 630038，630038 |
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| 摘 要： | 本文使用Southern杂交方法分析了胃癌组织中p53基因和Rb基因的缺失和重排;使用PCR-RFLP技术分析了p53基因第248位、249位密码子的点突变。研究结果显示:30例胃癌组织中9例有p53基因的缺失或重排;42例胃癌组织中两例有p53基因第248位密码子的点突变;15例胃癌组织中两例有Rb基因的缺失和重排。
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| 关 键 词： | 胃肿瘤 p53 Rb 基因 致癌基因 癌 |
A study on p53 and Rb genes in gastric cancer and juxta-cancerous tissue |
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| Wang Junru,Liu Weiwen,Wang Bing,et al. A study on p53 and Rb genes in gastric cancer and juxta-cancerous tissue[J]. Acta Academiae Medicinae Militaris Tertiae, 1993, 15(3): 198-202 |
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| Authors: | Wang Junru Liu Weiwen Wang Bing et al |
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| Abstract: | The deletion and rearrangement of p53 and Rb genes were studied in gastric cancer with Southern blot hybridization and the point mutation in 248 and 249 codons of p53 was studied with PCR-RFLP.It was found that deletion or rearrangement of p53 was seen in 9 cases out of 30 cases of gastric cancer and point mutation at 248 codon of p53 in 2 cases out of 42 cases,and deletion and rearrangement of Rb gene were seen in 2 cases out of 15 cases. |
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| Keywords: | stomach neoplasms oncogenes p53 genes Rb genes |
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