| FA方案用于急性髓系白血病不同治疗阶段疗效分析 |
| |
| 引用本文： | 欧阳凌云,刘晓力,杜庆锋,张钰,黄芬,张嵩,许娜,欧阳昭,孟凡义,周淑芸.FA方案用于急性髓系白血病不同治疗阶段疗效分析[J].中国肿瘤临床,2008,35(24):1385-1387. |
| |
| 作者姓名： | 欧阳凌云 刘晓力 杜庆锋 张钰 黄芬 张嵩 许娜 欧阳昭 孟凡义 周淑芸 |
| |
| 作者单位： | 南方医科大学南方医院血液科,广州市,510515 |
| |
| 基金项目： | 本文课题受广州市科技攻关计划一科技攻关引导项目资助
|
| |
| 摘 要： | 目的：评价氟达拉滨联合阿糖胞苷（FA）方案对急性髓系白血病（AML）不同治疗阶段的临床疗效。方法：根据应用FA方案治疗阶段将75例AML患者分为4组：①第1个疗程诱导化疗未缓解组21例;②2次及2次以上诱导治疗未缓解组21例;③早期复发组14例;④晚期复发组19例;其中后3组为难治复发性AML,比较不同组间疗效。结果：4组患者的完全缓解（CR）率分别为81.0%（17/21）、42.9%（9/21）、28.6%（4/14）及31.6%（6/19）。第1疗程诱导化疗未缓解组CR率明显高于复发难治性AML的CR率35.2%（19/54）（P=0.002）。Logistic回归分析结果显示既往化疗次数与CR率有显著相关性（P=0.027）。主要不良反应为骨髓抑制和继发感染。结论：对于第1个疗程化疗未缓解的AML患者,FA方案可作为一种有效的选择。
|
| 关 键 词： | 急性髓系白血病 氟达拉滨 阿糖胞苷 |
The Therapeutic Effect of Fludarabine and Cytarabine on Acute Myeloid Leukemia at Different Stages during Treatment |
| |
| OU YANG Lingyun,LIU Xiaoli,DU Qingfeng,ZHANG Yu,HOANG Fen,ZHANG Song,XU Na,OU Yangzhao,MENG Fanyi,ZHOU Shuyun.The Therapeutic Effect of Fludarabine and Cytarabine on Acute Myeloid Leukemia at Different Stages during Treatment[J].Chinese Journal of Clinical Oncology,2008,35(24):1385-1387. |
| |
| Authors: | OU YANG Lingyun LIU Xiaoli DU Qingfeng ZHANG Yu HOANG Fen ZHANG Song XU Na OU Yangzhao MENG Fanyi ZHOU Shuyun |
| |
| Institution: | OUYANG Lingyun,LIU Xiaoli,DU Qingfeng,ZHANG Yu,HUANG Fen,ZHANG Song,XU Na,OUYANGZhao,MENG Fanyi,ZHOU Shuyun Department of Hematology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China |
| |
| Abstract: | Objective:To evaluate the therapeutic effect of the fludarabine and cytarabine(FA)regimen on acutemyeloid leukemia(AML)at different phases during treatment.Methods:A total of 75 patients with AML were di-vided into 4 groups based on the outcome of previous treatments.Patients in Group 1 had no remission afterthe first course of induction chemotherapy(n=21).Patients in Group 2 had no remission after no less than twocourses of induction chemotherapy(n=21).Patients in Group 3 had early relapse(n=14).Patients i... |
| |
| Keywords: | Acute myeloid leukemia Fludarabine Cytarabine |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
