煤焦沥青对谷胱甘肽过氧化物酶影响的研究

向大白鼠气管内分别一次性注入２０、４０ｍｇ煤焦沥青（ＣＴＰ），４０天后大白鼠全血谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活性显著下降，６０天后下降更明显。肾ＧＳＨ－Ｐｘ活性也显著下降，４０ｍｇ剂量组较２０ｍｇ剂量组下降更明显（Ｐ＜０．０５），但肝ＧＳＨ－Ｐｘ活性无明显变化。焦化作业工人全血ＧＳＨ－Ｐｘ活性显著低于对照组（Ｐ＜０．００１），且随工龄增加而下降（Ｐ＜０．０５）。结果表明ＣＴＰ可降低ＧＳＨ－Ｐｘ活性，使机体脂质过氧化作用增强

The effect of coal tar pitch on glutathione peroxidase

The effect of coal tar pitch(CTP)on glutathione per oxidase(GSH-Px)had been studied with experimental rats and among workers who exposed occupationally to CTP of 20mg,40mg CTP powder suspended in 0.2ml sterile saline solution was intratracheally injected in to each rat, respectively. After forty days,the blood GSH-Px activity decreased obviously.Sixty days later, the blood GSH-Px activity declined very significantly, and the GSH-Px activity of kidney decreased obviously(P<0.05 ),but the GSH-Px activity of liver made no change. The GSH-Px activity of kidney after sixty days in 40mg dose group decreased more significantly than that in 20mg dose group(P<0.05).The blood GSH-Px activity in coking workers was significantly lower than that in controls(P<0.01). The results showed that CTP could decreased blood GSHPx activity and enhanced 63 the level of lipid peroxidation.