Hemodynamic characterization in experimental liver cirrhosis induced by thioacetamide administration |
| |
Authors: | Naoki Hori MD Dr Takeshi Okanoue MD Yoshihiko Sawa MD Takashi Mori MD Kei Kashima MD |
| |
Institution: | (1) Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji Kamigyoku, 602 Kyoto, Japan |
| |
Abstract: | Systemic and splanchnic hemodynamics in experimental liver cirrhosis in rats induced by thioacetamide were evaluated by the radioactive microsphere method. Cardiac output and regional blood flow were measured in conscious and anesthetized control and cirrhotic rats. The conscious thioacetamide-treatment rats had hyperdynamic circulation with an increased cardiac index (300±10 vs 258±3 ml/min/kg body weight,P<0.001) and increased portal venous inflow compared with the controls (64.60±2.4 vs 48.39±0.88 ml/min/kg body weight,P<0.001). Under pentobarbital anesthesia, the hyperdynamic circulation of the cirrhotic rats was maintained, with an increased cardiac index (276±7 vs 229±5 ml/min/kg body weight,P<0.001) and increased portal venous inflow compared with the controls (72.47±3.0 vs 54.08±1.2 ml/min/kg body weight,P<0.001). Portal pressure, portal venous resistance, and portal systemic shunting increased significantly while splanchnic arterial resistance decreased significantly in cirrhotic rats. Thioacetamide-induced cirrhosis is a useful model for the hemodynamic study of portal hypertension and remains useful in hemodynamic studies in the basal state under pentobarbital anesthesia. |
| |
Keywords: | portal hypertension radioactive microsphere method thioacetamide-induced cirrhosis pentobarbital anesthesia |
本文献已被 SpringerLink 等数据库收录! |
|