帕罗西汀与氯米帕明治疗难治性强迫症对照研究

目的：观察帕罗西汀和氯米帕明对难治性强迫症的疗效和不良反应。方法：对难治性强迫症患者60例，随机分为两组，分别用帕罗西汀和氯米帕明治疗8周。采用强迫症量表（Y-BOCS）和副反应量表（TESS）评价疗效及不良反应。结果：两药的总体疗效相仿。帕罗西汀对强迫行为疗效较好，不良反应小，尤其是心血管系统及抗胆碱能不良反应少。结论：帕罗西汀尤适用于以强迫行为为主的难治性强迫症患者。

Comparative study of paroxetine and clomipramine in treatment of patients with refractory obsessive-compulsive disorder

Objective:To compare the efficacy and side effects of paroxetine and clomipramine in the treatment of patients with refractory obsessive-compulsive disorder(OCD). Method:Sixty patients were randomly divided into two groups treated with paroxetine and clomipramine respectively for 8 weeks.The efficacy and side effects were monitored with clinical evaluation,Yale-Brown obsessive compulsive scale (Y-BOCS) and treatment emergant symptoms scale (TESS). Results:Both paroxetine and clomipramine were effective to refractory OCD,and there was no significant difference between two groups.But paroxetine was more effective to obsessive behavior and had less side effects. Conclusion:Paroxetine is a more suitable drug for treating with patients with refractory obsessive-compulsive disorder,especially for the patients with compulsive behavior.