组织细胞坏死性淋巴结炎32例临床病理分析

目的探讨组织细胞坏死性淋巴结炎(HNL)的临床病理学特点。方法回顾性分析32例HNL的临床资料,应用光镜观察其形态改变。结果病变淋巴结多位于颈部,呈轻、中度肿大(<3cm),男女之比为119,活检标本多破碎(22/32),形态特征为细胞碎片、增生的淋巴细胞及组织细胞构成大小不一凝固性坏死灶,无中性粒细胞。结论根据组织形态、细胞成分,组织细胞坏死性淋巴结炎可以明确诊断。

Histiocytic Necrotizing Lymphadenitis:A Clinicopathological Study of 32 Cases

Objective: To study the clinical and pathological features of 32 cases of histiocytic necrotizing lymphadenitis(HNL).Methods:The clinical and histopathologic features of 32 cases of HNL were analyzed.Results: The most common symptoms were cervical lymphadenopathy.All the lymph nodes were mild to median size (<3cm).The female to male ratio was 1.9 to 1.0.Fragmentation of the biopsy was a frequent features (22/32).Morphologically,it was characterized by variable sized necrosis that composed of eosinophilic granular debris and basophilic karyorrhectic debris admixed with proliferated lymphoid and histiocytic cells,and neutrophils were absent.Conclusions: HNL can be diagnosed with confidence with the architectural features and characteristic cytologic composition.