| FGFR2基因敲除小鼠模型的应用 |
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| 引用本文： | 陈志,曾照芳,陈林. FGFR2基因敲除小鼠模型的应用[J]. 国际遗传学杂志, 2007, 30(1): 25-28. DOI: 10.3760/cma.j.issn.1673-4386.2008.06.002 |
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| 作者姓名： | 陈志 曾照芳 陈林 |
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| 作者单位： | 400042,重庆,第三军医大学大坪医院野战外科研究所分子遗传实验室;400016,重庆医科大学检验系;400016,重庆医科大学检验系;400042,重庆,第三军医大学大坪医院野战外科研究所分子遗传实验室 |
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| 基金项目： | 国家重点基础研究发展规划项目（“973”项目）（2005CB522604）;国家自然基金杰出青年基金（30425023）;国家自然科学基金（30470947）;重庆市自然基金重点项目（CSTC.2004BA5016） |
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| 摘 要： | FGFR2基因与人类多种疾病密切相关。随着小鼠遗传工程技术的发展，利用基因敲除、转基因小鼠模型来研究基因与人类疾病的关系，已成为人们研究的热点。本文综述了FGFR2基因敲除小鼠模型近年来的研究近展，对几种FGFR2相关的基因敲除小鼠模型进行了系统的分类归纳，讨论了其在组织器官发育和相关人类疾病机制研究中的应用，并展望了其发展前景。
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| 关 键 词： | 成纤维细胞生长因子2型受体 基因敲除 小鼠模型 Apert综合征 |
| 收稿时间： | 2006-03-20 |
| 修稿时间： | 2006-03-17 |
The Application of FGFR2 Gene Knock-out Mouse Model |
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| CHEN Zhi,ZENG Zhao-fang,CHEN Lin. The Application of FGFR2 Gene Knock-out Mouse Model[J]. International JOurnal of Genetics, 2007, 30(1): 25-28. DOI: 10.3760/cma.j.issn.1673-4386.2008.06.002 |
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| Authors: | CHEN Zhi ZENG Zhao-fang CHEN Lin |
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| Affiliation: | 1. Laboratory of Medical Molecular Genetics, Daping Hospital, the Third Military Medical University, Chongqing 400042 ;2. Laborotary Department, Chongqing University of Medical Science, Chongqing 400016, China |
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| Abstract: | FGFR2 is closely related to many human diseases. With the development of mouse genetic engineering technology, the application of gene knock-out mouse model and transgenic mouse model to study the relationship between gene and human diseases is becoming the hot-spot of research. In this review, we summarize the recent advances in FGFR2-related gene knock-out mouse models, classify these models according to gene knock-out methods, and discuss their applications in the research of tissue or organ development and human disease mechanism. Furthermore, we discuss the future prospect about these models. |
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| Keywords: | Fibroblast growth factor receptor 2 Gene knock-out Mouse model Apert syndrome |
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