The effect of the intramolecular C–H⋯O interactions on the conformational preferences of bis-arylsulfones – 5-HT6 receptor antagonists and beyond |
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Authors: | Justyna Kalinowska-Tucik Jakub Staro Anna Krawczuk Stefan Mordalski Dawid Warszycki Grzegorz Sataa Adam S Hogendorf Andrzej J Bojarski |
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Institution: | Department of Crystal Chemistry and Crystal Physic, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Kraków Poland.; Department of Medicinal Chemistry, Institute of Pharmacology Polish Academy of Sciences, Smętna 12, 31-343 Kraków Poland |
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Abstract: | The development of compounds with enhanced activity and selectivity by a conserved spatial orientation of the pharmacophore elements has a long history in medicinal chemistry. Rigidified compounds are an example of this concept. However, the intramolecular interactions were seldom used as a basis for conformational restraints. Here, we show the weak intramolecular interactions that contribute to the relatively well-conserved geometry of N1-arylsulfonyl indole derivatives. The structure analysis along with quantum mechanics calculations revealed a crucial impact of the sulfonyl group on the compound geometry. The weak intramolecular C–H⋯O interaction stabilizes the mutual "facing" orientation of two aromatic fragments. These findings extend the pharmacological interpretation of the sulfonyl group role from the double hydrogen bond acceptor to the conformational scaffold based on intramolecular forces. This feature has, to date, been omitted in in silico drug discovery. Our results should increase the awareness of researchers to consider the conformational preference when designing new compounds or improving computational methods.The impact of weak intramolecular C–H⋯O interactions on the conformational stability of bis-arylsulfones is discussed, suggesting different role of sulfonyl group in the ligand – 5HT6 receptor interaction. |
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