Facile synthesis of α-alkoxyl amides via scandium-catalyzed oxidative reaction between ynamides and alcohols |
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| Authors: | Zhi-Xin Zhang Bo-Han Zhu Pei-Xi Xie Jia-Qi Tang Xin-Ling Li Chunyin Zhu Ying-Wu Yin Long-Wu Ye |
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| Affiliation: | State Key Laboratory of Physical Chemistry of Solid Surfaces, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 China.; School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013 China.; State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032 China |
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| Abstract: | A novel and efficient scandium-catalyzed oxidative reaction between ynamides and alcohols for the facile synthesis of various α-alkoxyl amides is reported in this paper. The reaction avoids the need for the use of α-diazo carbonyls which are unstable and may cause some safety concerns. Instead, by using alkynes as the starting materials, this protocol features readily available substrates, compatibility with a broad range of functional groups, simple procedure, mild reaction conditions, and high chemoselectivity.A novel scandium-catalyzed oxidative reaction between ynamides and alcohols has been developed, allowing the concise and efficient synthesis of various substituted α-alkoxyl amides. |
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