Synthesis,supramolecular organization and thermotropic phase behaviour of N-acyltris(hydroxymethyl)aminomethane |
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| Authors: | Sengan Megarajan Siva Bala Subramaniyan Sureshan Muthuswamy Savarimuthu Philip Anthony Jothi Arunachalam Dohyun Moon Anbazhagan Veerappan |
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| Affiliation: | School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur – 613401 Tamil Nadu India.; Beamline Department, Pohang Accelerator Laboratory, 80 Jigokro-127 beongil, Nam-gu, Pohang Korea, |
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| Abstract: | Herein, we reported the supramolecular organization of N-acyltris(hydroxymethyl)aminomethane (NATM) in the solid state as well as in aqueous solution. Single crystal X-ray diffraction revealed that NATM adopts a fully interdigitized structure. The thermodynamic parameters associated with thermotropic phase behaviour of NATM was determined by differential scanning calorimetry. The molecular packing and phase state of the NATM analyzed by laurdan and prodan fluorescence supports the formation of an interdigitized phase in aqueous solution. The potential application of the self-assembled NATM vesicles was demonstrated through entrapping model drug, Rhodamine B.Self assembly of N-acyltris(hydroxymethyl)aminomethane into interdigitized vesicles. |
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