A novel method to prepare tussah/Bombyx mori silk fibroin-based films |
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| Authors: | Richeng Yang Peng Wu Xinhong Wang Zekun Liu Cong Zhang Yinglu Shi Feng Zhang Baoqi Zuo |
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| Institution: | National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou 215123 China.; Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou 215006 China ; Medical College of Soochow University, Key Laboratory of Stem Cells and Biomedical Materials of Jiangsu Province and Chinese Ministry of Science and Technology, Suzhou 215123 China, |
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| Abstract: | The possibility of using silk fibroin in biomaterials for tissue engineering is a subject of broad interest. In this study, Bombyx mori/tussah silk fibroin (BSF/TSF) blend films were prepared by solution casting using CaCl2/formic acid as a co-solvent and water as a rinse solvent. The morphology, crystallinity, thermal resistance, mechanical properties and water contact angle of the blend films as well as the biocompatibility were investigated. The BSF/TSF blend films displayed a smooth surface and specific nanostructure in their cross-section, originating from the nanofibril-preservation during fibroin dissolution. The water rinse process induced the formation of a stable β-sheet structure. The BSF film showed superior mechanical properties to the TSF film, and the blending with TSF led to a significant reduction in the strength and elasticity of blend films. However, adding the TSF component could regulate the hydrophilic properties and enhance cell growth on the blend films. The BSF/TSF blend films with specific nanostructure, stable secondary structure, appropriate mechanical properties, and good biocompatibility, are promising candidates for application in regenerative medicine.A novel method is reported to prepare tussah/Bombyx mori silk fibroin blend films featured transparent, flexible and biocompatible. |
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