Regio-selective and stereo-selective hydrosilylation of internal alkynes catalyzed by ruthenium complexes |
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| Authors: | Wenhao Dai Xiaowei Wu Chunpu Li Rui Zhang Jiang Wang Hong Liu |
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| Affiliation: | School of Pharmacy, China Pharmaceutical University, Nanjing 210009 Jiangsu China ; Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203 China.; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049 China |
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| Abstract: | In this study, ruthenium(ii)-catalyzed direct hydrosilylation of internal alkynes with high regio-selectivity and stereo-selectivity is reported. This title transformation led to various vinylsilanes in good to excellent yields. This approach features mild reaction conditions, low catalyst loading, air-stability, and good functional group tolerance. Furthermore, gram-scale preparation and some transformations of vinylsilanes were carried out, which further underscored its synthetic utility and applicability.In this study, ruthenium(ii)-catalyzed direct hydrosilylation of internal alkynes with high regio-selectivity and stereo-selectivity is reported. |
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