Direct C–H functionalization of difluoroboron dipyrromethenes (BODIPYs) at β-position by iodonium salts |
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| Authors: | Wenming Ren Huaijiang Xiang Chengyuan Peng Zulipali Musha Jingjing Chen Xin Li Ruimin Huang Youhong Hu |
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| Institution: | State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203 China.; College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058 China ; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 110039 China |
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| Abstract: | A copper-catalyzed direct C–H arylation or vinylation of BODIPYs at the β-position by iodonium salts has been developed, which provides facile access to a variety of mono-substituted BODIPY dyes. Interestingly, β-styryl BODIPY compound 9b exhibits apparent cytotoxicity after laser irradiation, which has great potential for photodynamic therapy.A copper-catalyzed direct C–H arylation or vinylation of BODIPYs at the β-position by iodonium salts has been developed and β-styryl BODIPY 9b has great potential for photodynamic therapy. |
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