Novel steroidal saponins with cytotoxic activities from the roots of Ophiopogon japonicus (L. f.) Ker-Gawl |
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| Authors: | Yan Wu Su-Xia Bi Zhen Huang Jin Qi Bo-Yang Yu |
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| Affiliation: | Jiangsu Key Laboratory of TCM Evaluation and Translational Research, China Pharmaceutical University, Nanjing 211198 People''s Republic of China, Fax: +86-25-86185158, +86-25-86185157 |
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| Abstract: | Six new steroidal saponins (1–6) and one known steroidal saponin (7) were obtained from the roots of Ophiopogon japonicus (L. f.) Ker-Gawl. Their structures were determined by the detailed analysis of extensive nuclear magnetic resonance and mass spectroscopic data. The in vitro cytotoxic activities of these compounds against MDA-MB-435, HepG2 and A549 cell lines were also investigated.Novel cytotoxic steroidal saponins from the roots of Ophiopogon japonicus (L. f.) Ker-Gawl. |
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