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Synthesis of diversely substituted bis-pyrrolizidino/ thiopyrrolizidino oxindolo/acenaphthyleno curcuminoids via sequential azomethine ylide cycloaddition |
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| Authors: | Meenakshi Singh Abhijit Hazra Yogesh P Bharitkar Ritu Kalia Ashutosh Sahoo Sneha Saha V Ravichandiran Shekhar Ghosh Nirup B Mondal |
| Institution: | National Institute of Pharmaceutical Education and Research (NIPER), (IICB Campus), 4, Raja S. C. Mullick Road, Jadavpur, Kolkata – 700 032 India ; Department of Organic and Medicinal Chemistry, Indian Institute of Chemical Biology, Council of Scientific and Industrial Research, 4, Raja S. C. Mullick Road, Jadavpur, Kolkata – 700 032 India, |
| Abstract: | Curcumin has been transformed to several diversely substituted bis-pyrrolizidino/thiopyrrolizidino oxindolo/acenaphthyleno curcuminoids via a sequential azomethine ylide cycloaddition reaction using isatins/acenaphthoquinone and proline/thioproline as the reagents. The products were separated via extensive chromatography and characterized by 1D/2D NMR and HRMS analysis.Curcumin has been transformed to several diversely substituted bis-pyrrolizidino/thiopyrrolizidino oxindolo/acenaphthyleno curcuminoids via a sequential azomethine ylide cycloaddition reaction. |
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