One-pot three component synthesis of 5-allyl-1,2,3-triazoles using copper(i) acetylides |
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| Authors: | Parigi Raghavendar Reddy Lianji Cui Jae-Sang Ryu |
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| Affiliation: | College of Pharmacy & Graduate School of Pharmaceutical Sciences, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-Gu, Seoul 03760 Republic of Korea, |
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| Abstract: | One-pot three-component reactions using copper(i) acetylide, azide, allyl iodide, and NaOH have been developed. The reactions proceed smoothly at room temperature to afford 5-allyl-1,2,3-triazoles, which can be further transformed into a variety of 1,2,3-triazole-fused bi-/tricyclic scaffolds. This method offers the most efficient, convenient, and practical route towards useful polycyclic scaffolds in moderate to excellent yields.A one-pot three-component synthetic route toward 5-allyl-1,2,3-triazoles using copper(i) acetylide has been developed, which allows further transformation to important tricyclic scaffolds. |
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