Preparation of prolinamide with adamantane for aldol reaction catalysis in brine and separation using a poly(AN-MA-β-CD) nanofibrous film via host–guest interaction |
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Authors: | Rui Wang Enjie Xu Zhenming Su Haifeng Duan Jinjin Wang Longqi Xue Yingjie Lin Yaoxian Li Zhonglin Wei Qingbiao Yang |
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Institution: | College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012 P. R. China.; Security Check, Jilin Province 566B Guigu Street, Changchun 130012 P. R. China |
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Abstract: | Prolinamides with double-H potential were prepared and employed as organocatalysts in asymmetric aldol reactions. The catalyst with adamantane showed improved catalytic activity, which was further enhanced by using brine as the solvent. A series of aldol reactions in brine at 0 °C provided good yields (up to 98%) with high diastereoselectivities (>99 : 1) and enantioselectivities (>99%). The prepared catalyst was adsorbed by a nanofibrous film of poly(AN-MA-β-CD) via host–guest interaction in the reaction system. The catalyst was separated from the film by applying ultrasound, with a total recovery of 96.2%. The catalyst was reused up to five times without a significant change in diastereoselectivity and enantioselectivity.Prolinamide with adamantane catalyzed the aldol reaction. The reaction of cyclohexanone with m-nitrobenzaldehyde assessed recyclability of catalyst. After run, the catalyst was adsorbed with nanofibrous of polymer via host–guest interaction. |
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