Novel oligopeptide nanoprobe for targeted cancer cell imaging |
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Authors: | Wen-Qiang Ding Si-Yong Qin Yin-Jia Cheng Yi-Han Ma Ai-Qing Zhang |
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Affiliation: | College of Chemistry and Materials Science, South-Central University for Nationalities, Wuhan 430074 P. R. China, |
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Abstract: | Here we designed and constructed a tryptophan-phenylalanine-phenylalanine-tryptophan (WFFW) tetrapeptide, which generated photostable and tunable fluorescence emission signals from 340 nm to 500 nm. The WFFW tetrapeptide could self-assemble into a spherical nanostructure with enhanced fluorescence intensity. Driven by π–π stacking and hydrogen bond interaction, WFFW co-assembled with arginine-glycine-aspartic acid (RGD) modified WFFW to form a cancer-targeted fluorescent nanoprobe, which could selectively image the cancer cells.Co-assembly of WFFW tetrapeptide and RGDWFFW heptapeptide generated the photostable and fluorescence-tunable nanoprobe, which could selectively image the cancer cells. |
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