Diagnosis of trisomy 18 in monozygotic twins by cordocentesis |
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| Authors: | D M Shah P Jeanty V G Dev J E Ulm J Phillips |
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| Affiliation: | Division of Maternal-Fetal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee. |
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| Abstract: | The incidence of monozygotic twins with trisomy 18 is 1 in 1,000,000 births. We report a case diagnosed prenatally with lymphocyte culture from fetal blood samples obtained by cordocentesis. Fetal growth lag and structural malformations detected by ultrasonography indicated chromosomal abnormality. A saline solution infusion technique ensured that cordocentesis obtained a sample from each twin. |
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