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川芎嗪对顺铂耳毒性保护作用的实验研究
引用本文:孙宪昌,张文娟,康颂建.川芎嗪对顺铂耳毒性保护作用的实验研究[J].泰山医学院学报,2010,31(7):483-486.
作者姓名:孙宪昌  张文娟  康颂建
作者单位:1. 泰山医学院生理学教研室,山东,泰安,271000
2. 泰山医学院附属泰山医院,山东,泰安,271000
基金项目:泰山医学院青年科研计划项目 
摘    要:目的探讨活血化瘀中药川芎嗪是否对顺铂的耳毒性具有保护作用。方法将听力正常的30只豚鼠随机分为3组,每组10只。对照组:生理盐水3 ml/(kg.d)腹腔注射6天;顺铂组:顺铂3 mg/(kg.d)腹腔注射6天;顺铂加川芎嗪组:先腹腔注射川芎嗪140 mg/(kg.d)3天,从第4天起腹腔注射川芎嗪140 mg/(kg.d)后再注射顺铂3 mg/(kg.d)6天。给药前后通过听觉脑干诱发电位(ABR)检测豚鼠听功能的变化;然后在麻醉状态下断头取耳蜗,半数标本切片后用DNA末端转移酶介导的缺口末端标记法(TUNEL)检测耳蜗内细胞凋亡情况;半数标本进行耳蜗基底膜铺片观察毛细胞形态及酶学变化。结果顺铂组用药后ABR阈值升高,毛细胞受损,琥珀酸脱氢酶(SDH)活性减弱,有部分毛细胞凋亡,与对照组及川芎嗪组比较差异具有统计学意义(P〈0.05)。顺铂加川芎嗪组用药后ABR阈值升高,毛细胞受损较轻,凋亡细胞较少,与顺铂组比较差异有统计学意义(P〈0.05)。结论川芎嗪能降低顺铂的耳毒性。

关 键 词:顺铂  耳毒性  川芎嗪注射液  毛细胞  凋亡

The study on protection of ligustrazine against cisplatin-induced ototoxicity
SUN Xian-chang,ZHANG Wen-juan,KANG Song-jian.The study on protection of ligustrazine against cisplatin-induced ototoxicity[J].Journal of Taishan Medical College,2010,31(7):483-486.
Authors:SUN Xian-chang  ZHANG Wen-juan  KANG Song-jian
Institution:SUN Xian-chang1,ZHANG Wen-juan2,KANG Song-jian1 (1.Dept.of Physiology,Taishan Medical University,Taian 271000,China,2.Taian Central Hospital,China)
Abstract:Objective: To explore the protective effect of ligustrazine against cisplatin-induced ototoxicity.Methods: Thirty adult guinea pigs were divided into three groups.Group A received saline as controls.Group B received cisplatin(3 mg/kg) injections for 6 consecutive days.Group C first received ligustrazine(140 mg/kg) for 3 days,and then received both cisplatin(3 mg/kg) and ligustrazine(140 mg/kg) for 6 consecutive days.Both ears of all the animals were tested with auditory brain stem response(ABR) before and o...
Keywords:cisplatin  ototoxicity  ligustrazine  hair cells  apopotosis  
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