| 双唑泰阴道泡腾片安全性研究 |
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| 引用本文： | 孙慧玲,房娜,陈百泉.双唑泰阴道泡腾片安全性研究[J].河南大学学报(医学版),2006,25(2):22-23. |
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| 作者姓名： | 孙慧玲 房娜 陈百泉 |
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| 作者单位： | 1. 河南大学药学院,药理教研室,河南,开封,475001
2. 河南大学医学院,生化教研室,河南,开封,475001 |
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| 摘 要： | 目的:为探讨双唑泰阴道泡腾片临床应用的安全性。方法:检测家兔阴道和眼局部用药有无刺激性以及豚鼠皮肤用药的过敏性反应,同时用生理盐水对照。结果:家兔阴道和眼局部用药以及豚鼠皮肤给药和生理盐水对照组比较无明显差异。结论:双唑泰阴道泡腾片对家兔阴道和眼局部刺激性试验为阴性,豚鼠皮肤过敏性试验阴性,提示临床应用具安全性。
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| 关 键 词： | 双唑泰 阴道泡腾片 刺激性 皮肤过敏性试验 安全性 |
| 文章编号： | 1672-7606(2006)02-0022-02 |
| 收稿时间： | 2005-12-18 |
| 修稿时间： | 2005年12月18 |
Study on the safety of Shuangzuotai vihinal effervescent tablets |
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| SUN Hui-ling,FANG Na,CHEN Bai-quan.Study on the safety of Shuangzuotai vihinal effervescent tablets[J].Journal of Henan University,2006,25(2):22-23. |
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| Authors: | SUN Hui-ling FANG Na CHEN Bai-quan |
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| Institution: | 1. Pharmacological Section, Pharmaceutical College of Henan University, Kaifeng475001, Henan, China; 2. Department of Biochemistry, Medical College of Henan University, Kaifeng 475001, Henan, China |
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| Abstract: | Objective: To investigate the Safety of Shuangzuotai Vagina effervescent Tablets.Methods: The stimulation on vagina mucous membrane and eye mucous membrane was tested in rabbits and skin allergic reaction was examined in guinea pig,which were compared with control group administered by NS.Results: There is no significant difference between tested groups in stimulation and hypersensitivity compared with those of the NS group.Conclusion: Shuangzuotai viginal effervescent tablet doesn′t cause local stimulation on rabbits'vagina and eye mucous membrane and doesn′t cause skin allergic reaction in guinea pig,which suggests that Shuangzuotai is safe to use in clinical application. |
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| Keywords: | Shuangzuotai Vagina Effervescent Tablets irritation Skin allergy reaction Safety |
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