内皮素含量变化在诊断脑血管病发生发展中的价值

目的 :通过内皮素 ( ET)含量变化观察 ET在脑血管病 ( CVD)发生、发展中的作用。方法 :用放免测定方法动态观察 1 0 4例 CVD患者不同时期血浆中内皮素含量。结果 :脑出血 ( CH)和脑梗死 ( CI)患者急性期血浆 ET水平分别为 1 39.9± 60 .5 pg/ml和1 2 3.5± 5 0 .9pg/ml,与对照组 ( 83.0± 37.2 pg/ml)比较有显著升高 ( P<0 .0 0 1 ) ;CH病人30 d后血浆中 ET含量与对照组比较 ,仍然是升高的 ( P<0 .0 5 ) ,但 CI患者 30 d后血浆中ET含量与对照组比较已无显著性差异 ( P>0 .0 5 )。结论 :ET在 CVD的发生发展中可能具有重要作用 ,动态观察血浆中 ET含量的变化对于判断 CVD的变化可能有一定的帮助

Diagnostic values of change in endothelin in occurence and development of cerebral vascular diseases

Objective: To explore the role of change in plasma endothelin(ET) in occurence and development of cerebral vascular diseases(CVD). Methods: The concentration of plasma ET was measured by Radioimmunoassay in 104 patients with CVD during acute and recovery phases. Results: The concentrations of plasma ET in acute phase were significantly increased in cerebral hemorrhage (CH 139.9±60.5pg/ml, P<0.001) and cerebral infarction (CI 123.5±50.9pg/ml,P<0.01), compared with that of control group(83.0±37.2 pg/ml). The concentrations of plasma ET in 30 days after onset of CH were still higher than that of control group (P<0.05). But the concentrations of plasma ET were not differenct between patients with CI and control group in 30 days after onset (P>0.05). Conclusion: ET may be played important roles in development of CVD and the changes in plasma ET observed dynamically should be helpful for estimating the change in CVD.