Host genetic factors associated with hepatocellular carcinoma in patients with hepatitis C virus infection: A systematic review |
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| Authors: | A J Walker C J Peacock V Pedergnana STOP‐HCV Consortium W L Irving |
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| Institution: | 1. National Institute for Health research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, University of Nottingham, Nottingham, UK;2. Centre for Evidence Based Medicine, Department of Primary Care Health Sciences, University of Oxford, Oxford, UK;3. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK |
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| Abstract: | Hepatitis C virus (HCV)‐infected patients are at risk of developing hepatocellular carcinoma (HCC). Individuals at heightened risk could be targeted by intensive follow‐up surveillance. We have conducted a systematic review of the literature to identify host genetic predisposition to HCC in HCV‐infected patients. A comprehensive search of Medline and Embase databases was performed, and the strength of evidence of associations for each gene on development of HCC was evaluated. We identified 166 relevant studies, relating to 137 different genes, or combinations thereof. Seventeen genes were classified as having “good” evidence of an association, a significant association was observed for 37 genes but this finding had not yet been replicated, 56 genes had mixed or limited evidence of an association, and 27 genes showed no association. IFNL3 | |
| Keywords: | genetic predisposition risk stratification |
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