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Hormone levels of follicular fluids with and without oocytes in patients who received gonadotropin-releasing hormone analogues and gonadotropins in an in vitro fertilization program
Authors:Iphigenia Phocas  Themis Mantzavinos  Dimitris Rizos  Fotini Dimitriadou  Katerina Arvaniti  Pantelis A. Zourlas
Affiliation:(1) Second Department of Obstetrics and Gynecology, University of Athens, Athens, Greece;(2) Euromedica Institute of High Technology, Athens, Greece;(3) Hormonological Laboratory, Second Department of Obstetrics and Gynecology, University of Athens, Areteion University Hospital, 76, Vas. Sophias Ave., GR-115 28 Athens, Greece
Abstract:Background Are follicles where no oocytes are retrieved ldquoempty folliclesrdquo?Methods The levels of estradiol (E2), progesterone (P), testosterone (T), cortisol (F), and prolactin (PRL) of follicular fluids (FF) aspirated individually from 34 randomly selected IVF patients in whom no oocytes were recovered were compared with the respective hormone levels of FF obtained from the same patients when oocytes were retrieved. Two FF without oocytes of a 35th patient in whom no oocytes were retrieved were analyzed.Results Hormones did not differ significantly in the paired samples, while in the two FF of the 35th woman they were in agreement with cystic follicles.Conclusions It is necessary to differentiate aspirated follicles where no oocytes are retrieved from the ldquoempty follicle syndrome,rdquo which was not observed in the IVF series studied and should be rare in IVF patients.
Keywords:steroid hormones  prolactin  follicular fluid with/without oocytes  empty follicle
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