Late antibody-mediated rejection by de novo donor HLA-DP-specific antibody after renal transplantation: A case report |
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| Authors: | Pietro E. Cippà ,Ariana Gaspert,Christoph Etter,Zehra Guenduez,Sylvie Ferrari-Lacraz,Barbara Rü si,Thomas Fehr |
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| Affiliation: | 1. Division of Nephrology, University Hospital Zurich, Switzerland;2. Institute of Surgical Pathology, University Hospital Zurich, Switzerland;3. Interdisciplinary HLA Typing Laboratory, University Hospital Zurich, Switzerland;4. Swiss National Reference Laboratory for Histocompatibility, Geneva University Hospital, Switzerland |
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| Abstract: | The role of donor HLA-DP-specific antibodies after renal transplantation is controversial, and only preformed HLA-DP-specific antibodies have been shown to mediate rejection. Here we present a case of late humoral rejection mediated by de novo donor HLA-DP-specific antibodies in a non-sensitized recipient. This unique case demonstrates the pathogenic role of de novo anti-DP antibodies and suggests that HLA-DP matching might be relevant for renal transplantation. |
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| Keywords: | AMR, antibody-mediated-rejection eGFR, estimated glomerular filtration rate MFI, mean fluorescence intensity |
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