Capacidad diagnóstica del antígeno carcinoembrionario |
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Authors: | Antonio Cerezo Ruiz Francisco Rosa Jiménez José Antonio Lobón Hernández Francisco Javier Gómez Jiménez |
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Institution: | 1. Aparato Digestivo. Hospital Alta Resolución Alcaudete, Agencia Sanitaria Alto Guadalquivir, Consejería de Salud y Bienestar Social, Junta de Andalucía;2. Medicina Interna, Hospital Alta Resolución Alcaudete, Agencia Sanitaria Alto Guadalquivir, Consejería de Salud y Bienestar Social, Junta de Andalucía;3. Departamento de Medicina, Facultad de Medicina, Universidad de Granada, GranadaEspaña |
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Abstract: | IntroductionThere is little information on the oncologic diagnostic accuracy of carcinoembryonic antigen (CEA) levels more than 3-fold above normal.ObjetivesTo determine the prevalence of underlying cancer in patients with mild CEA elevation and the mean cost per patient of CEA determination.MethodsA retrospective study was carried out in all patients with CEA elevation (3-10 ng/ml) and suspicion of cancer referred to the gastroenterology or internal medicine outpatient units from 2001 to 2007.ResultsWe studied 100 patients (60 men and 40 women), with a mean age of 67.4 ± 14.2 years and baseline CEA of 5.8 ± 1.7 ng/ml. The most important symptoms and signs were laboratory abnormalities (19 patients 19%]). Cancer was diagnosed in 4 patients (one gastric, 2 lung and one colon). Among patients without malignancies, 49 patients (49%) had no related processes, and 47 (47%) had benign diseases. During follow-up, one laryngeal cancer, one acute myeloid leukemia, and one colon cancer were detected (54.3 ± 24.6 months). We found no differences between baseline CEA levels in patients with and without cancer (6.6 ± 2.4 vs. 5.8 ± 1.7 ng/ml, p = 0.2). The mean cost per patient was 503.6 ± 257.6 €.ConclusionsCancer was detected in a small proportion (7%) of patients with mild CEA elevation. The study of these patients is directly and indirectly associated with a not inconsiderable cost. |
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Keywords: | Antí geno carcinoembrionario Marcadores tumorales |
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