Upregulated expression of human alpha-defensins 1, 2 and 3 in hypercholesteremia and its relationship with serum lipid levels |
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Authors: | Yun-Xi Li Chao-Qun Lin Da-Yu Shi Shu-Ying Zeng Wen-Sheng Li |
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Affiliation: | 1. Department of Laboratory, Southern Medical University Affiliated the First People’s Hospital of Shunde, Foshan, China;2. Department of Pathology, Southern Medical University Affiliated the First People’s Hospital of Shunde, Foshan, China;3. Department of Cardiology, Southern Medical University Affiliated the First People’s Hospital of Shunde, Foshan, China |
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Abstract: | Human alpha-defensins are natural antimicrobial peptides of neutrophils evolved in host defense reactions and circulating nonstressed alpha-defensins may be associated with serum lipid levels. The aim of this work was to examine whether the expression of alpha-defensins 1, 2 and 3 genes are changed and whether this changes are reversed following treatment in patients with hypercholesteremia. A total of 40 individuals of hypercholesteremia group were studied, compared with 40 individuals of normal control group. Protein levels and gene expression levels of alpha-defensins 1, 2 and 3 were significantly higher in patients with hypercholesteremia compared with subjects in normal control group. In patients with hypercholesteremia, protein levels of alpha-defensins 1, 2 and 3 correlated positively with the levels of total cholesterol and low-density lipoprotein cholesterol. Protein levels and gene expression levels of alpha-defensins 1, 2 and 3 were decreased significantly after a treatment with atorvastatin calcium 20 mg daily compared with the patients before the treatment. Our results suggest that the expression of alpha-defensins 1, 2 and 3 genes is involved in dyslipidemia in patients with hypercholesteremia. |
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Keywords: | HNPs, Human neutrophil peptides DEFA, alpha-defensins gene BMI, body mass index SBP, systolic blood pressure DBP, diastolic blood pressure CRP, C-reactive protein Tch, total cholesterol EDTA-K2, dipotassium ethylene diamine tetraacetate ELISA, enzyme linked immunosorbent assay |
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