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A single nucleotide polymorphism −35 kb T > C (rs9264942) is strongly associated with psoriasis vulgaris depending on HLA-Cw06 |
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| Authors: | Edyta Majorczyk Łukasz Matusiak Izabela Nowak Aneta Pietkiewicz-Sworowska Wioleta Łuszczek Jacek C. Szepietowski Piotr Kuśnierczyk |
| Affiliation: | 1. Laboratory of Immunogenetics and Tissue Immunology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, ul. Rudolfa Weigla 12, 53-114 Wroc?aw, Poland;2. Chair of Biochemistry and Physiology, Institute of Physiotherapy, Faculty of Physical Education and Physiotherapy, Opole University of Technology, ul. Prószkowska 76, 45-758 Opole, Poland;3. Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, ul. T. Cha?ubińskiego 1, 50-368 Wroc?aw, Poland |
| Abstract: | HLA class I molecules play a role both in viral infection control and in autoimmune diseases development. rs9264942T > C polymorphism in HLA-C gene was found to impact on HLA-C surface expression level and to be associated with HIV-1 control. It was found that these HLA alleles which protect against AIDS are associated with autoimmune disease e.g. psoriasis vulgaris (PsV). Whether rs9264942 SNP is associated with PsV was investigated here. rs9264942T > C was genotyped in 292 PsV patients, and 254 controls using TaqMan Genotyping Assay. |
| Keywords: | PsV, psoriasis vulgaris ADO, age at disease onset group |
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