IL10 polymorphisms associated with Behçet’s disease in Chinese Han |
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| Authors: | Ziyan Wu Wenjie Zheng Juanjuan Xu Fei Sun Hua ChenPing Li Si ChenMing Shen Wen ZhangXin You Qingjun WuFengchun Zhang Yongzhe Li |
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| Affiliation: | Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China |
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| Abstract: | ObjectiveIL-10 is a potent anti-inflammatory cytokine that plays important roles in the pathogenesis of Behçet’s disease (BD). Two genome-wide association studies have identified IL10 as a potential risk factor for BD. Here, we investigated the association between IL10 polymorphisms and BD in Chinese Han.Methods407 BD patients and 679 healthy controls were enrolled, and genotyped by Sequenom MassArray system (Sequenom iPLEX assay, San Diego, CA).ResultsThe frequency of risk allele of rs1800871 was notably higher in BD patients than in controls (71.9% vs. 66.2%, OR: 1.30, 95%CI: 1.08–1.58, pc = 0.024). Similarly, rs1518111, which showed strong linkage disequilibrium (r2 = 1) with allele rs1800871, was also associated with BD (pc = 0.026). Rs3021094 was in association with BD in a dominant model (pc = 0.035), and the haplotype (GACC) formed by rs1518111, rs3021094, rs3790622, and rs1800871 was associated with BD (pc = 0.023). Results obtained from meta-analysis combined with our data showed that rs1800871 and rs1518111 were associated with BD.ConclusionIL10 may be the susceptibility gene for BD in Chinese Han population. |
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| Keywords: | BD, Behç et&rsquo s disease SLE, systemic lupus rythematosus RA, rheumatoid arthritis UC, ulcerative colitis GWAS, genome-wide association studies SNP, single nucleotide polymorphism LD, linkage disequilibrium |
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